{"id":20806,"date":"2017-04-03T21:59:23","date_gmt":"2017-04-03T21:59:23","guid":{"rendered":"http:\/\/www.oracletutoring.ca\/blog\/?p=20806"},"modified":"2017-04-03T21:59:23","modified_gmt":"2017-04-03T21:59:23","slug":"biology-what-is-competitive-inhibition","status":"publish","type":"post","link":"https:\/\/www.oracletutoring.ca\/blog\/biology-what-is-competitive-inhibition\/","title":{"rendered":"Biology:  what is competitive inhibition?"},"content":{"rendered":"<h1>Tutoring biology, you might be asked about competitive inhibition.  The tutor explains it.<\/h1>\n<p>In my <a href=\"?p=3034\">November 25, 2013 post,<\/a> I explain what an enzyme is.  Simply put, an enzyme is a biological catalyst that the body uses to speed up a chemical process.  An enzyme is not consumed by the reaction, but works alongside it, so can be reused.<\/p>\n<p><em>Competitive inhibition<\/em> reduces the effectiveness of an enzyme, possibly with fatality.  Along with some preliminary ideas, here&#8217;s how it happens:<\/p>\n<ol>\n<li>The molecule an enzyme works on is called the <em>substrate<\/em>.  The enzyme speeds the transformation of the substrate into what the body needs.<\/li>\n<li>The substrate, normally, binds to the enzyme at what&#8217;s called the enzyme&#8217;s <em>active site<\/em> in order for the enzyme to work on it.<\/li>\n<li>Therefore, let&#8217;s imagine that enzyme E works on substrate S to make necessary molecule M.<\/li>\n<li>Once S transforms to M, enzyme E is released; E is not attracted to M.<\/li>\n<li>Competitive inhibition starts with the arrival of a different substrate, \u00acS, that is\n<ul>\n<li>attractive to enzyme E at the active site<\/li>\n<li>not transformable to the necessary molecule M<\/li>\n<li>will not become M, so will not release E (or not very quickly, anyway)<\/li>\n<\/ul>\n<li>The result is that E becomes busy with \u00acS, so its active site is inaccessible to S.<\/li>\n<li>Without access to the active site of E, S can&#8217;t transform into M.<\/li>\n<li>The body needs M; without it, health consequences, possibly even death, will manifest.<\/li>\n<\/ol>\n<p>Such is the mechanism of competitive inhibition.  Some poisons are competitive inhibitors.<\/p>\n<p>Source:<\/p>\n<p><u>Biology 12 Module 1<\/u>.  Open School BC, 2007.<\/p>\n<p>Mader, Sylvia.  <u>Inquiry into Life<\/u>, 11th ed.  Toronto:  McGraw Hill, 2006.<\/p>\n<p>Jack of <a href=\"https:\/\/www.oracletutoring.ca\">Oracle Tutoring by Jack and Diane,<\/a> Campbell River, BC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tutoring biology, you might be asked about competitive inhibition. The tutor explains it. In my November 25, 2013 post, I explain what an enzyme is. Simply put, an enzyme is a biological catalyst that the body uses to speed up &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"more-link\" href=\"https:\/\/www.oracletutoring.ca\/blog\/biology-what-is-competitive-inhibition\/\"> <span class=\"screen-reader-text\">Biology:  what is competitive inhibition?<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,8],"tags":[2223,2220,2221,28,2222],"class_list":["post-20806","post","type-post","status-publish","format-standard","hentry","category-biology","category-biology-12","tag-active-site","tag-catalyst","tag-competitive-inhibition","tag-enzyme","tag-substrate"],"_links":{"self":[{"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/posts\/20806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/comments?post=20806"}],"version-history":[{"count":15,"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/posts\/20806\/revisions"}],"predecessor-version":[{"id":20821,"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/posts\/20806\/revisions\/20821"}],"wp:attachment":[{"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/media?parent=20806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/categories?post=20806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.oracletutoring.ca\/blog\/wp-json\/wp\/v2\/tags?post=20806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}